How can the two be distinguished on Abdominal MR?
Haemochromatosis, also spelled hemochromatosis, is a hereditary disease characterized by inappropriate dietary iron metabolism (making it an iron overload disorder), which causes the surfeit of iron in a few body tissues.
Hemosiderosis is a condition affecting the lungs which results in bleeding from tiny alveolar capillary.
Focal hemosiderosis can result from recurrent hemorrhage in an organ. Iron liberated from extravasated RBCs is deposited inwardly that organ, and significant hemosiderin deposits may eventually develop. The organ usually affected is the lung, and the bring usually is recurrent pulmonary hemorrhage, any idiopathic (eg, Goodpasture's syndrome) or that occurring in conditions cause chronic pulmonary hypertension (eg, primary pulmonary hypertension, pulmonary fibrosis, severe mitral stenosis). Occasionally, iron loss from these episodes causes iron not as much as anemia, because iron in the tissue cannot be reused.
Renal hemosiderosis can result from extensive intravascular hemolysis (see Anemias Caused by Hemolysis). Free Hb is filter at the glomerulus, and iron is deposited in the kidneys. The renal parenchyma is not destabilized, but severe hemosiderinuria may result in iron lesser amount.
Please see the web page for more details on Hemochromatosis and Hemosiderosis.
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